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R.PerveenA.et al (2021a)

Chem Res Toxicol 24(8):11691214

3c and d)

The analgesic effects appeared to differ from typical opioid analgesia they developed more slowly, persisted longer after administration ceased, and showed different patterns of tolerance development

Initial research suggested that Bregs can suppress immune responses mediated by Th17 cells and improve collagen-induced arthritis through the manufacturing of IL-10